Replacing basement membrane extracts
During the fall, a group of European 3Rs organisations has arranged a webinar series about replacing basement membrane extracts (BMEs).
This webinar series from a cross-European group of 3Rs centres, delivered during October-December 2021, aimed to explore the challenges and opportunities when it comes to replacing BMEs, from research through to application.
Reliable and reproducible in vitro models are essential for replacing the use of animals in scientific procedures. The availability of complex 3D models, including organoids and microphysiological systems, has in recent years strengthened this replacement potential. However, many in vitro models are dependent on animal-derived products, for example to support cell growth or differentiation, which can show batch-to-batch variation and can involve animal suffering in their production. Replacing these with non-animal derived products provides an opportunity to increase the reproducibility of in vitro models and remove the use of animals completely.
All webinars were recorded and are published on the NC3Rs website.